Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.34 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 3/20 | 0.33 |
| ▸ | PPARA | Q07869 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4697099 | 0.89 | HSD11B1 (0.53) | HSD11B1ALDH1A1MCOLN3PPARGPPARA | |
| SCHEMBL4698707 | 0.87 | HSD11B1 (0.52) | HSD11B1ALDH1A1MCOLN3 | |
| SCHEMBL4701145 | 0.86 | HSD11B1 (0.51) | HSD11B1ALDH1A1MCOLN3CASR | |
| SCHEMBL4696865 | 0.84 | HSD11B1 (0.47) | HSD11B1ALDH1A1PPARGPPARA | |
| SCHEMBL4697453 | 0.79 | HSD11B1 (0.57) | HSD11B1ALDH1A1MCOLN3CASR | |
| SCHEMBL4697260 | 0.78 | HSD11B1 (0.48) | HSD11B1ALDH1A1MCOLN3 | |
| SCHEMBL4697458 | 0.77 | HSD11B1 (0.58) | HSD11B1ALDH1A1MCOLN3 | |
| SCHEMBL14143453 | 0.77 | HSD11B1 (0.60) | HSD11B1ALDH1A1MCOLN3 | |
| SCHEMBL4697308 | 0.76 | HSD11B1 (0.59) | HSD11B1ALDH1A1MCOLN3 | |
| SCHEMBL4751912 | 0.75 | HSD11B1 (0.56) | HSD11B1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1830841-B1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2008-07-02 | — | — | EP | claimed |