Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.51 |
| ▸ | RARB | P10826 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 2/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | CASR | P41180 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4698707 | 0.97 | HSD11B1 (0.52) | HSD11B1RARBALDH1A1MCOLN3CES2 | |
| SCHEMBL4697040 | 0.88 | HSD11B1 (0.55) | HSD11B1RARBALDH1A1KMT2A | |
| SCHEMBL4698234 | 0.86 | HSD11B1 (0.48) | HSD11B1ALDH1A1MCOLN3CASR | |
| SCHEMBL4751912 | 0.85 | HSD11B1 (0.56) | HSD11B1RARBALDH1A1KMT2A | |
| SCHEMBL4700534 | 0.83 | HSD11B1 (0.48) | HSD11B1ALDH1A1KMT2AMERTK | |
| SCHEMBL4701592 | 0.80 | HSD11B1 (0.49) | HSD11B1ALDH1A1KMT2AMERTK | |
| SCHEMBL4697482 | 0.79 | HSD11B1 (0.61) | HSD11B1ALDH1A1MCOLN3CES2KMT2A | |
| SCHEMBL4696769 | 0.78 | HSD11B1 (0.60) | HSD11B1ALDH1A1MCOLN3KMT2A | |
| SCHEMBL4698725 | 0.78 | HSD11B1 (0.57) | HSD11B1ALDH1A1MCOLN3CES2CASR | |
| SCHEMBL14143454 | 0.77 | HSD11B1 (0.61) | HSD11B1ALDH1A1MCOLN3CES2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1830841-B1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2008-07-02 | — | — | EP | claimed |