Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 12/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200523 | 0.85 | GRM5 (0.53) | GRM5NPC1RAB9AMAPTPKM | |
| SCHEMBL4700157 | 0.83 | GRM5 (0.67) | GRM5NPC1RAB9A | |
| SCHEMBL4698743 | 0.83 | GRM5 (0.67) | GRM5NPC1RAB9AMAPTPKM | |
| SCHEMBL4701228 | 0.81 | GRM5 (0.72) | GRM5 | |
| SCHEMBL13683938 | 0.81 | GRM5 (0.53) | GRM5NPC1RAB9AMAPT | |
| SCHEMBL13683904 | 0.78 | GRM5 (0.57) | GRM5NPC1RAB9AMAPTPKM | |
| SCHEMBL13683903 | 0.77 | GRM5 (0.46) | GRM5NPC1RAB9AMAPT | |
| SCHEMBL4700359 | 0.76 | GRM5 (0.54) | GRM5NPC1RAB9AMAPT | |
| SCHEMBL13684502 | 0.76 | GRM5 (0.45) | GRM5NPC1RAB9AMAPTPKM | |
| SCHEMBL4702208 | 0.71 | GRM5 (0.58) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1434773-B1 | HETEROARYL SUBSTITUTED TETRAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK & CO INC (US) | 2008-05-21 | — | — | EP | claimed |
| WO-2004030637-A2 | TREATMENT OF OBESITY AND OTHER DISORDERS ASSOCIATED WITH EXCESSIVE FOOD INTAKE | MERCK & CO., INC. (US) | 2004-04-15 | — | — | WO | claimed |
| US-7253190-B2 | Heteroaryl substituted tetrazole modulators of metabotrophic glutamate receptor-5 | MERCK & CO., INC. (US) | 2007-08-07 | — | — | US | disclosed |
| US-7253190-B2 | Heteroaryl substituted tetrazole modulators of metabotrophic glutamate receptor-5 | MERCK & CO., INC. (US) | 2007-08-07 | — | — | US | disclosed |