Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 10/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13683938 | 0.84 | GRM5 (0.53) | GRM5NPC1RAB9AMAPTCHRNB2 | |
| SCHEMBL14200523 | 0.76 | GRM5 (0.53) | GRM5NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL4698325 | 0.76 | GRM5 (0.53) | GRM5NPC1RAB9AMAPT | |
| SCHEMBL13683903 | 0.76 | GRM5 (0.46) | GRM5NPC1RAB9AMAPT | |
| SCHEMBL4698743 | 0.75 | GRM5 (0.67) | GRM5NPC1RAB9AMAPT | |
| SCHEMBL4701228 | 0.73 | GRM5 (0.72) | GRM5 | |
| SCHEMBL17062366 | 0.71 | LMNA (0.66) | GRM5USP2ALDH1A1LMNATDP1 | |
| SCHEMBL4158354 | 0.70 | GRM5 (1.00) | GRM5 | |
| SCHEMBL4701728 | 0.70 | GRM5 (0.83) | GRM5 | |
| SCHEMBL13683904 | 0.70 | GRM5 (0.57) | GRM5NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1434773-B1 | HETEROARYL SUBSTITUTED TETRAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK & CO INC (US) | 2008-05-21 | — | — | EP | claimed |
| US-7253190-B2 | Heteroaryl substituted tetrazole modulators of metabotrophic glutamate receptor-5 | MERCK & CO., INC. (US) | 2007-08-07 | — | — | US | disclosed |
| US-7253190-B2 | Heteroaryl substituted tetrazole modulators of metabotrophic glutamate receptor-5 | MERCK & CO., INC. (US) | 2007-08-07 | — | — | US | disclosed |