Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMD14 | O00487 | 3/20 | 0.44 |
| ▸ | COPS5 | Q92905 | 3/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.39 |
| ▸ | CCR1 | P32246 | 2/20 | 0.38 |
| ▸ | CCR8 | P51685 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14045321 | 0.77 | PSMD14 (0.44) | PSMD14COPS5CCR1CCR8KDM4E | |
| SCHEMBL3064498 | 0.77 | NR4A2 (0.46) | PSMD14COPS5NR4A2CCR1CCR8 | |
| SCHEMBL4698412 | 0.77 | PSMD14 (0.39) | PSMD14COPS5NR4A2CCR1CCR8 | |
| SCHEMBL27418389 | 0.77 | NR4A2 (0.38) | PSMD14COPS5NR4A2CCR1CCR8 | |
| SCHEMBL6422325 | 0.77 | PSMD14 (0.62) | PSMD14COPS5NR4A2CCR1CCR8 | |
| SCHEMBL5558125 | 0.77 | NR4A2 (0.38) | PSMD14COPS5NR4A2CCR1CCR8 | |
| SCHEMBL3204532 | 0.77 | NR4A2 (0.38) | PSMD14COPS5NR4A2CCR1CCR8 | |
| SCHEMBL29377991 | 0.74 | KDM4E (0.65) | KDM4EALDH1A1NPC1RAB9ACYP2A6 | |
| SCHEMBL28081897 | 0.74 | KDM4E (0.65) | KDM4EALDH1A1NPC1RAB9ACYP2A6 | |
| SCHEMBL22333784 | 0.73 | CCR1 (0.62) | PSMD14COPS5CCR1CCR8L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660483-B1 | 8-(1-PIPERAZINYL)-QUINOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LTD (GB) | 2008-12-24 | — | — | EP | disclosed |
| US-20080275040-A1 | 8-(1-Piperazinyl)-Quinoline Derivatives and Their Use in the Treatment of Cns Disorders | GLAXO GROUP LIMITED (GB) | 2008-11-06 | — | — | US | disclosed |
| EP-1660483-A1 | 8-(1-PIPERAZINYL)-QUINOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005021530-A1 | 8- (1-PIPERAZINYL)- QUINOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2005-03-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275040-A1 | 8-(1-Piperazinyl)-Quinoline Derivatives and Their Use in the Treatment of Cns Disorders | PMP22, AQP4, SLC18A2 | PSMD14 4305/4885COPS5 1983/4885NR4A2 999/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.