Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.47 |
| ▸ | MEN1 | O00255 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4698601 | 1.00 | MAPT (0.50) | MAPTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4698577 | 0.87 | MAPT (0.58) | MAPTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4698447 | 0.87 | MAPT (0.58) | MAPTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL17561003 | 0.85 | MAPT (0.56) | MAPTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4698394 | 0.78 | ALDH1A1 (0.53) | MAPTALDH1A1RAB9ANPC1KMT2A | |
| SCHEMBL7748700 | 0.78 | MAPT (0.55) | MAPTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL31105723 | 0.78 | MAPT (0.55) | MAPTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL7748696 | 0.78 | MAPT (0.55) | MAPTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7747576 | 0.76 | MAPT (0.54) | MAPTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7747578 | 0.76 | MAPT (0.54) | MAPTALDH1A1RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309544-B1 | COMPOUNDS ACTING AS MELANOCORTIN RECEPTOR LIGANDS | ACURE PHARMA AB (SE) | 2008-11-05 | — | — | EP | claimed |
| US-7153881-B2 | Compounds acting as melanocortin receptor ligands | ACURE PHARMA AB (SE) | 2006-12-26 | — | — | US | claimed |
| EP-1309544-B1 | COMPOUNDS ACTING AS MELANOCORTIN RECEPTOR LIGANDS | ACURE PHARMA AB (SE) | 2008-11-05 | — | — | EP | disclosed |
| US-7153881-B2 | Compounds acting as melanocortin receptor ligands | ACURE PHARMA AB (SE) | 2006-12-26 | — | — | US | disclosed |