Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL464353 | 0.91 | HDAC8 (0.76) | HDAC8ALDH1A1TSHRMAPTHDAC6 | |
| SCHEMBL469843 | 0.81 | HDAC8 (0.47) | HDAC8ALDH1A1TSHRHDAC6HPGD | |
| SCHEMBL415810 | 0.80 | HDAC8 (0.48) | HDAC8ALDH1A1TSHRHDAC6HPGD | |
| SCHEMBL446824 | 0.77 | HDAC8 (1.00) | HDAC8MAPTHDAC6POLB | |
| SCHEMBL21292761 | 0.76 | KMT2A (0.62) | ALDH1A1TSHRMAPTHPGDKMT2A | |
| SCHEMBL10463170 | 0.75 | POLB (0.50) | HDAC8ALDH1A1TSHRCYP3A4HPGD | |
| SCHEMBL8384541 | 0.73 | PSEN1 (0.64) | HDAC8ALDH1A1TSHRCYP3A4KMT2A | |
| SCHEMBL415355 | 0.73 | MTNR1A (0.41) | HDAC8GAA | |
| SCHEMBL416742 | 0.72 | MAPT (0.47) | ALDH1A1MAPTHSD17B10 | |
| SCHEMBL355191 | 0.72 | HDAC8 (0.59) | HDAC8ALDH1A1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012031993-A1 | NOVEL N-HYDROXY-BENZAMIDES FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-15 | — | — | WO | disclosed |