Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.53 |
| ▸ | RAB9A | P51151 | 7/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL219006 | 0.79 | GPR119 (0.45) | NPC1RAB9ASMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL2624454 | 0.78 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL221090 | 0.76 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL2739940 | 0.74 | SIRT1 (0.65) | SMN1; SMN2ALDH1A1HPGDHSD17B10TP53 | |
| SCHEMBL2740017 | 0.74 | SIRT1 (0.66) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL2760428 | 0.72 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL31631307 | 0.70 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL221887 | 0.70 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL2387340 | 0.69 | LRRK2 (0.53) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL11643357 | 0.69 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910385-A1 | BENZOTHIAZOLES AND THIAZOLOPYRIDINES AS SIRTUIN MODULATORS | Sirtris Pharmaceuticals, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007019346-A1 | BENZOTHIAZOLES AND THIAZOLOPYRIDINES AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2007-02-15 | — | — | WO | disclosed |