Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 7/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2662336 | 0.93 | HTR4 (0.42) | HTR4ADORA2BHTR7NPC1GAA | |
| SCHEMBL2662043 | 0.90 | HTR1D (0.44) | NPC1PTGER4GAAGFERHRH3 | |
| SCHEMBL2661450 | 0.89 | TSHR (0.44) | HTR4ADORA2BHTR7NPC1PTGER4 | |
| SCHEMBL2651673 | 0.88 | PTGER4 (0.45) | HTR4ADORA2BHTR7NPC1PTGER4 | |
| SCHEMBL2652470 | 0.88 | HTR1D (0.45) | HTR4ADORA2BHTR7NPC1PTGER4 | |
| SCHEMBL2650037 | 0.87 | TSHR (0.42) | HTR4ADORA2BHTR7NPC1GAA | |
| SCHEMBL2651644 | 0.87 | JAK2 (0.42) | HTR4ADORA2BNPC1GAAGFER | |
| SCHEMBL2653364 | 0.87 | HTR7 (0.45) | HTR4ADORA2BHTR7NPC1DRD2 | |
| SCHEMBL2650857 | 0.87 | TSHR (0.43) | HTR4ADORA2BHTR7NPC1PTGER4 | |
| SCHEMBL2662153 | 0.87 | GAA (0.44) | HTR4ADORA2BHTR7NPC1PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615896-B1 | NOVEL BENZIMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THESE COMPOUNDS | NEUROSEARCH AS (DK) | 2008-04-23 | — | — | EP | disclosed |