Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 8/20 | 0.47 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.41 |
| ▸ | CDK9 | P50750 | 2/20 | 0.41 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL57014 | 0.82 | NTRK1 (0.55) | NTRK1 | |
| SCHEMBL4694092 | 0.81 | NTRK1 (0.48) | NTRK1NUAK1CCNT1CDK9 | |
| SCHEMBL4696455 | 0.81 | NTRK1 (0.64) | NTRK1NUAK1CCNT1CDK9MAPT | |
| SCHEMBL4698140 | 0.79 | NTRK1 (0.66) | NTRK1NUAK1LMNAALDH1A1HSD17B10 | |
| SCHEMBL4695215 | 0.77 | NUAK1 (0.61) | NTRK1NUAK1NTRK3NTRK2 | |
| SCHEMBL4698219 | 0.72 | NTRK1 (0.59) | NTRK1NUAK1CCNT1CDK9 | |
| SCHEMBL56396 | 0.72 | NTRK1 (0.53) | NTRK1 | |
| SCHEMBL4699080 | 0.71 | NTRK1 (0.52) | NTRK1MAPK1 | |
| SCHEMBL57840 | 0.71 | NTRK1 (0.59) | NTRK1MAPK1 | |
| SCHEMBL4698236 | 0.71 | NTRK1 (0.47) | NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853588-B1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-06-18 | — | — | EP | disclosed |