Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 13/20 | 0.69 |
| ▸ | PDE4A | P27815 | 12/20 | 0.69 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.69 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.69 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | CASP3 | P42574 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.57 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.57 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4703070 | 0.86 | PDE4D (0.75) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL4701218 | 0.83 | PDE4D (0.78) | PDE4DPDE4APDE4BPDE4CPOLB | |
| SCHEMBL4698780 | 0.82 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL12371963 | 0.80 | PDE4D (0.77) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL4700531 | 0.78 | PDE4D (0.74) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL6985339 | 0.78 | PDE4A (0.58) | PDE4DPDE4APDE4BPDE4CPOLB | |
| SCHEMBL4702549 | 0.76 | PDE4A (0.60) | PDE4DPDE4APDE4BPDE4CPOLB | |
| Hydrochloric Acid SCHEMBL4701167 | 0.75 | PDE4A (0.59) | PDE4DPDE4APDE4BPDE4CPOLB | |
| SCHEMBL9588701 | 0.75 | MAPT (0.51) | PDE4DPOLBNPC1CASP3ATM | |
| SCHEMBL3899046 | 0.75 | PDE4B (0.58) | PDE4DPDE4APDE4BPDE4CPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952832-B1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | DARWIN DISCOVERY LTD (GB) | 2008-08-27 | — | — | EP | claimed |
| EP-0952832-B1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | DARWIN DISCOVERY LTD (GB) | 2008-08-27 | — | — | EP | disclosed |