Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.58 |
| ▸ | KCNMA1 | Q12791 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALPL | P05186 | 1/20 | 0.45 |
| ▸ | ALPI | P09923 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4699328 | 0.78 | PDE4D (0.69) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL4703070 | 0.75 | PDE4D (0.75) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4698780 | 0.73 | PDE4D (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3899046 | 0.73 | PDE4B (0.58) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL4702549 | 0.72 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL14363413 | 0.72 | MEN1 (0.62) | KCNMA1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL12371963 | 0.72 | PDE4D (0.77) | PDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL4701167 | 0.71 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL2269427 | 0.70 | GAA (0.62) | ALDH1A1SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL4700531 | 0.70 | PDE4D (0.74) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946541-B1 | QUINOLINES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2003-07-30 | — | — | EP | disclosed |
| US-6069151-A | Quinolines and their therapeutic use | DARWIN DISCOVERY, LTD. (GB) | 2000-05-30 | — | — | US | disclosed |
| EP-0946541-A1 | QUINOLINES AND THEIR THERAPEUTIC USE | Darwin Discovery Limited (GB) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998020007-A1 | QUINOLINES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LIMITED (GB) | 1998-05-14 | — | — | WO | disclosed |