Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 14/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 3/20 | 0.41 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3814544 | 0.90 | KDM4E (0.52) | MEN1KMT2AMALT1 | |
| SCHEMBL3832436 | 0.83 | KDM4E (0.47) | MEN1KMT2AMALT1 | |
| SCHEMBL3576482 | 0.80 | SLC6A7 (0.55) | MGLL | |
| SCHEMBL4075764 | 0.76 | ESR2 (0.36) | MELKMEN1KMT2A | |
| SCHEMBL3579395 | 0.74 | SLC6A7 (0.55) | MEN1KMT2AMALT1 | |
| SCHEMBL3812149 | 0.72 | KDM4E (0.54) | MEN1KMT2AMGLLMALT1 | |
| SCHEMBL4754060 | 0.71 | SLC6A7 (0.67) | MEN1KMT2A | |
| SCHEMBL3853233 | 0.71 | SLC6A7 (0.54) | MEN1KMT2AMALT1 | |
| SCHEMBL3815687 | 0.70 | MALT1 (0.48) | MEN1KMT2AMGLLMALT1 | |
| SCHEMBL1135093 | 0.70 | SLC6A7 (0.68) | MGLLMALT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893212-A2 | MULTICYCLIC COMPOUNDS AND METHODS OF THEIR USE | Lexicon Pharmaceuticals, Inc. (US) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006124748-A2 | MULTICYCLIC COMPOUNDS AND METHODS OF THEIR USE | LEXICON GENETICS INCORPORATED (US) | 2006-11-23 | — | — | WO | disclosed |