Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A7 | Q99884 | 10/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | TSHR | P16473 | 2/20 | 0.67 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3819645 | 0.88 | ALDH1A1 (0.72) | SLC6A7ALDH1A1TSHRKDM4EL3MBTL1 | |
| SCHEMBL3821678 | 0.85 | ALDH1A1 (0.65) | SLC6A7ALDH1A1TSHRSLC6A3KDM4E | |
| SCHEMBL4698854 | 0.83 | SLC6A7 (0.70) | SLC6A7ALDH1A1TSHRSLC6A3KDM4E | |
| SCHEMBL3817716 | 0.82 | SLC6A7 (0.63) | SLC6A7ALDH1A1TSHRSLC6A3KDM4E | |
| SCHEMBL3585906 | 0.81 | SLC6A7 (0.77) | SLC6A7ALDH1A1TSHRSLC6A3KDM4E | |
| SCHEMBL3814544 | 0.81 | KDM4E (0.52) | SLC6A7ALDH1A1TSHRSLC6A3KDM4E | |
| SCHEMBL4750978 | 0.81 | SLC6A7 (0.71) | SLC6A7ALDH1A1TSHRSLC6A3KDM4E | |
| SCHEMBL3820146 | 0.80 | SLC6A7 (0.65) | SLC6A7ALDH1A1TSHRSLC6A3KDM4E | |
| SCHEMBL5935798 | 0.79 | SLC6A7 (0.59) | SLC6A7ALDH1A1TSHRSLC6A3KDM4E | |
| SCHEMBL3586157 | 0.78 | SLC6A7 (1.00) | SLC6A7ALDH1A1TSHRSLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893212-A2 | MULTICYCLIC COMPOUNDS AND METHODS OF THEIR USE | Lexicon Pharmaceuticals, Inc. (US) | 2008-03-05 | — | — | EP | claimed |
| WO-2006124748-A2 | MULTICYCLIC COMPOUNDS AND METHODS OF THEIR USE | LEXICON GENETICS INCORPORATED (US) | 2006-11-23 | — | — | WO | claimed |