SCHEMBL4699659

SCHEMBL4699659

COC(=O)Oc1cc(C(=O)NCc2ccccc2)ncn1

nearest known ligand 0.68

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MMP13 P45452 5/20 0.68
SMN1; SMN2 Q16637 3/20 0.50
EGFR P00533 2/20 0.49
CYP1A2 P05177 1/20 0.49
CYP2D6 P10635 1/20 0.49
CYP2C19 P33261 1/20 0.49
HPGD P15428 5/20 0.46
HSD17B10 Q99714 2/20 0.46
ALDH1A1 P00352 2/20 0.46
KDM4E B2RXH2 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
LCK P06239 1/20 0.46
POLB P06746 1/20 0.45
GLA P06280 2/20 0.45
TP53 P04637 1/20 0.45
MEN1 O00255 1/20 0.45
KMT2A Q03164 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4718323 0.89 MMP13 (0.52) MMP13SMN1; SMN2HSD17B10POLB
SCHEMBL4717001 0.87 MMP13 (0.56) MMP13SMN1; SMN2CYP2D6HPGDHSD17B10
SCHEMBL6474351 0.82 MMP13 (0.81) MMP13SMN1; SMN2EGFRCYP1A2CYP2D6
SCHEMBL4718343 0.82 MMP13 (0.74) MMP13CYP1A2CYP2C19HPGDALDH1A1
SCHEMBL4720434 0.80 MMP13 (0.56) MMP13SMN1; SMN2CYP2D6HPGDHSD17B10
SCHEMBL4720402 0.79 MMP13 (0.58) MMP13SMN1; SMN2HSD17B10ALDH1A1POLB
SCHEMBL15692554 0.78 MMP13 (0.91) MMP13SMN1; SMN2EGFRCYP1A2CYP2D6
SCHEMBL4719389 0.78 RAB9A (0.53) MMP13HPGDALDH1A1POLB
SCHEMBL13456939 0.76 MMP13 (0.76) MMP13SMN1; SMN2EGFRCYP1A2CYP2D6
SCHEMBL9200180 0.76 HPGD (0.52) MMP13SMN1; SMN2EGFRCYP1A2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1455790-B1 USE OF PYRIDINE-2,4-DICARBOXYLIC ACID DIAMIDES AND OF PYRIMIDINE-4,6-DICARBOXYLIC ACID DIAMIDES FOR SELECTIVE COLLAGENASE INHIBITION SANOFI AVENTIS DEUTSCHLAND (DE) 2008-03-26 EP disclosed
EP-1587803-A1 PYRIMIDINE-4,6-DICARBOXYLIC ACID DIAMIDES FOR USE AS SELECTIVE MMP 13 INHIBITORS Aventis Pharma Deutschland GmbH (DE) 2005-10-26 EP disclosed
EP-1455790-A1 USE OF PYRIDINE-2,4-DICARBOXYLIC ACID DIAMIDES AND OF PYRIMIDINE-4,6-DICARBOXYLIC ACID DIAMIDES FOR SELECTIVE COLLAGENASE INHIBITION Aventis Pharma Deutschland GmbH (DE) 2004-09-15 EP disclosed
WO-2004060883-A1 PYRIMIDINE-4,6-DICARBOXYLIC ACID DIAMIDES FOR USE AS SELECTIVE MMP 13 INHIBITORS AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2004-07-22 WO disclosed
WO-2003049738-A1 USE OF PYRIDINE-2,4-DICARBOXYLIC ACID DIAMIDES AND OF PYRIMIDINE-4,6-DICARBOXYLIC ACID DIAMIDES FOR SELECTIVE COLLAGENASE INHIBITION AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2003-06-19 WO disclosed