Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 9/20 | 0.43 |
| ▸ | CTSS | P25774 | 9/20 | 0.43 |
| ▸ | CTSB | P07858 | 8/20 | 0.43 |
| ▸ | CTSK | P43235 | 9/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5872541 | 1.00 | CTSL (0.43) | CTSLCTSSCTSBCTSKMAPKAPK2 | |
| SCHEMBL4698928 | 0.87 | CTSL (0.43) | CTSLCTSSCTSBCTSKMAPKAPK2 | |
| SCHEMBL4704442 | 0.85 | CTSS (0.46) | CTSSCTSK | |
| SCHEMBL4703250 | 0.84 | CTSL (0.46) | CTSLCTSSCTSBCTSKMAPKAPK2 | |
| SCHEMBL4703327 | 0.84 | CTSL (0.46) | CTSLCTSSCTSBCTSKMAPKAPK2 | |
| SCHEMBL4699478 | 0.81 | CTSL (0.45) | CTSLCTSSCTSBCTSKMAPKAPK2 | |
| SCHEMBL4703494 | 0.81 | CTSL (0.44) | CTSLCTSSCTSBCTSKMAPKAPK2 | |
| SCHEMBL6233400 | 0.81 | CTSL (0.44) | CTSLCTSSCTSBCTSKMAPKAPK2 | |
| SCHEMBL4704327 | 0.79 | CTSL (0.51) | CTSLCTSSCTSBCTSKACVR1 | |
| SCHEMBL4698649 | 0.78 | CTSL (0.48) | CTSLCTSSCTSBCTSKACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1372655-B1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2008-10-01 | — | — | EP | disclosed |
| EP-1372655-A4 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA INC (CA) | 2005-10-12 | — | — | EP | disclosed |
| EP-1372655-A2 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | Merck Frosst Canada & Co. (CA) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002069901-A2 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2002-09-12 | — | — | WO | disclosed |