Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 6/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.39 |
| ▸ | IKBKB | O14920 | 4/20 | 0.34 |
| ▸ | CHUK | O15111 | 3/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24263560 | 0.83 | TYK2 (0.38) | TYK2PDE4DIKBKBCHUKPDE10A | |
| SCHEMBL19336869 | 0.81 | TYK2 (0.43) | TYK2IKBKBCHUKALOX15CYP1A2 | |
| SCHEMBL469938 | 0.77 | KDM4E (0.41) | CYP1A2PDE10A | |
| SCHEMBL24263271 | 0.75 | TYK2 (0.43) | TYK2PDE4D | |
| SCHEMBL16556413 | 0.73 | BRD4 (0.51) | ALOX15 | |
| SCHEMBL14902322 | 0.68 | SYK (0.35) | IKBKBHTR6 | |
| SCHEMBL31285448 | 0.65 | TYK2 (0.34) | TYK2PDE4D | |
| SCHEMBL103800 | 0.64 | KDM4E (0.62) | CYP1A2 | |
| SCHEMBL23181522 | 0.63 | UHRF1 (0.35) | CYP1A2 | |
| SCHEMBL3018000 | 0.63 | PDE10A (0.36) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023178234-A1 | TYK2 INHIBITORS AND USES THEREOF | ALUMIS INC. (US) | 2023-09-21 | — | — | WO | disclosed |
| WO-2023178235-A1 | TYK2 INHIBITORS AND USES THEREOF | ALUMIS INC. (US) | 2023-09-21 | — | — | WO | disclosed |
| WO-2012032031-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-03-15 | — | — | WO | disclosed |