Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 15/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 4/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24263473 | 0.84 | TYK2 (0.53) | TYK2PDE4DJAK2JAK1JAK3 | |
| SCHEMBL469978 | 0.75 | TYK2 (0.39) | TYK2PDE4D | |
| SCHEMBL24263269 | 0.73 | TYK2 (0.55) | TYK2PDE4D | |
| SCHEMBL24263303 | 0.72 | TYK2 (0.55) | TYK2PDE4D | |
| SCHEMBL24263488 | 0.72 | TYK2 (0.50) | TYK2PDE4D | |
| SCHEMBL24263537 | 0.69 | TYK2 (0.70) | TYK2 | |
| SCHEMBL24263560 | 0.69 | TYK2 (0.38) | TYK2PDE4D | |
| SCHEMBL229747 | 0.69 | RAB9A (0.59) | GRM5KDR | |
| SCHEMBL21571881 | 0.68 | TYK2 (0.46) | TYK2PDE4DJAK2JAK1JAK3 | |
| SCHEMBL20504498 | 0.67 | TYK2 (0.58) | TYK2PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022037694-A1 | A CLASS OF FIVE- AND SIX-MEMBERED HETEROCYCLIC COMPOUNDS AND USE THEREOF AS PROTEIN RECEPTOR KINASE INHIBITORS | 轶诺(浙江)药业有限公司 | 2022-02-24 | — | — | WO | disclosed |