Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 8/20 | 0.37 |
| ▸ | MAPT | P10636 | 7/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1775586 | 0.84 | POLB (0.37) | POLBALDH1A1LMNATP53MAPT | |
| SCHEMBL4707430 | 0.77 | MAPT (0.40) | POLBALDH1A1LMNATP53MAPT | |
| SCHEMBL1774554 | 0.68 | LMNA (0.37) | POLBALDH1A1LMNATP53MAPT | |
| SCHEMBL1775861 | 0.67 | ABL1 (0.33) | — | |
| SCHEMBL12097681 | 0.65 | POLB (0.41) | POLBALDH1A1LMNATP53MAPT | |
| SCHEMBL4707031 | 0.63 | LMNA (0.38) | POLBALDH1A1LMNATP53MAPT | |
| SCHEMBL4705810 | 0.63 | ALDH1A1 (0.36) | POLBALDH1A1LMNATP53MAPT | |
| SCHEMBL12097860 | 0.62 | KDM4E (0.34) | POLBALDH1A1LMNATP53MAPT | |
| SCHEMBL4707643 | 0.62 | POLB (0.35) | POLBALDH1A1LMNATP53MAPT | |
| SCHEMBL4710518 | 0.61 | POLB (0.34) | POLBALDH1A1LMNATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831226-A4 | CHIRAL FUSED 1,2 IMIDAZO 4,5-c RING COMPOUNDS | 3M INNOVATIVE PROPERTIES CO (US) | 2008-11-05 | — | — | EP | disclosed |
| EP-1831226-A2 | CHIRAL FUSED 1,2 IMIDAZO 4,5-c RING COMPOUNDS | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006074003-A2 | CHIRAL FUSED [1,2]IMIDAZO[4,5-c] RING COMPOUNDS | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2006-07-13 | — | — | WO | disclosed |