Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 5/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP4B1 | P13584 | 1/20 | 0.36 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.36 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4700236 | 1.00 | CRHR1 (0.46) | CRHR1GABRG2GABRB3GABRA2GABRA1 | |
| Hydrochloric Acid SCHEMBL4702917 | 0.99 | CRHR1 (0.46) | CRHR1GABRG2GABRB3GABRA2GABRA1 | |
| Hydrochloric Acid SCHEMBL4698197 | 0.99 | CRHR1 (0.46) | CRHR1GABRG2GABRB3GABRA2GABRA1 | |
| SCHEMBL4700622 | 0.80 | CRHR1 (0.33) | CRHR1 | |
| SCHEMBL4700618 | 0.80 | CRHR1 (0.33) | CRHR1 | |
| SCHEMBL3367525 | 0.80 | KMT2A (0.48) | CRHR1GABRG2GABRB3GABRA2CYP1A1 | |
| Hydrochloric Acid SCHEMBL4698818 | 0.79 | CRHR1 (0.32) | CRHR1 | |
| Hydrochloric Acid SCHEMBL4702286 | 0.79 | CRHR1 (0.32) | CRHR1 | |
| SCHEMBL3364849 | 0.79 | CRHR1 (0.43) | CRHR1GABRG2GABRB3GABRA2GABRA1 | |
| SCHEMBL3363713 | 0.78 | CRHR1 (0.43) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569911-B1 | INDAZOLE DERIVATIVES AS CRF ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-02 | — | — | EP | claimed |
| US-7214699-B2 | Indazole derivatives as CRF antagonists | ROCHE PALO ALTO LLC (US) | 2007-05-08 | — | — | US | disclosed |