Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 10/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.33 |
| ▸ | PGR | P06401 | 4/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 4/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4702339 | 0.83 | CRHR1 (0.44) | CRHR1 | |
| SCHEMBL3362854 | 0.81 | CRHR1 (0.44) | CRHR1 | |
| SCHEMBL4702341 | 0.79 | CRHR1 (0.40) | CRHR1MCL1 | |
| SCHEMBL4700544 | 0.77 | CRHR1 (0.40) | CRHR1 | |
| SCHEMBL14500905 | 0.75 | CRHR1 (0.48) | CRHR1 | |
| SCHEMBL4700539 | 0.74 | CRHR1 (0.55) | CRHR1 | |
| Hydrochloric Acid SCHEMBL4698015 | 0.74 | CRHR1 (0.54) | CRHR1 | |
| SCHEMBL4702328 | 0.72 | CRHR1 (0.64) | CRHR1 | |
| SCHEMBL6025193 | 0.72 | CRHR1 (0.42) | CRHR1 | |
| SCHEMBL4702330 | 0.70 | CRHR1 (0.41) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569911-B1 | INDAZOLE DERIVATIVES AS CRF ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-02 | — | — | EP | claimed |