Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 6/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 10/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4702271 | 0.83 | CRHR1 (0.39) | CRHR1 | |
| SCHEMBL4698855 | 0.83 | CRHR1 (0.44) | CRHR1LMNA | |
| Hydrochloric Acid SCHEMBL4697950 | 0.82 | CRHR1 (0.44) | CRHR1LMNA | |
| SCHEMBL4700572 | 0.80 | CRHR1 (0.41) | CRHR1 | |
| SCHEMBL4757562 | 0.80 | SMN1; SMN2 (0.39) | CRHR1LMNATP53 | |
| SCHEMBL4701270 | 0.80 | CHRM2 (0.39) | CRHR1HRH4LMNA | |
| SCHEMBL4702626 | 0.79 | HEXA (0.43) | TP53 | |
| SCHEMBL6025193 | 0.79 | CRHR1 (0.42) | CRHR1HRH4 | |
| SCHEMBL4700546 | 0.79 | CRHR1 (0.43) | CRHR1MCL1 | |
| SCHEMBL4702330 | 0.79 | CRHR1 (0.41) | CRHR1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569911-B1 | INDAZOLE DERIVATIVES AS CRF ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-02 | — | — | EP | claimed |