Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4703130 | 0.79 | RXFP1 (0.41) | SMN1; SMN2ALDH1A1KDM4ENPC1MEN1 | |
| SCHEMBL492013 | 0.75 | ELANE (0.49) | SMN1; SMN2ALDH1A1MAPTKDM4ERAB9A | |
| SCHEMBL31011039 | 0.73 | MAPT (0.50) | SMN1; SMN2ALDH1A1MAPTKDM4ERAB9A | |
| SCHEMBL25810203 | 0.73 | MAPT (0.50) | SMN1; SMN2ALDH1A1MAPTKDM4ERAB9A | |
| SCHEMBL31053285 | 0.72 | ALDH1A1 (0.55) | SMN1; SMN2ALDH1A1MAPTKDM4ERAB9A | |
| SCHEMBL3635258 | 0.72 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1MAPTNPSR1MAPK1 | |
| SCHEMBL1635139 | 0.72 | ELANE (0.49) | SMN1; SMN2ALDH1A1MAPTKDM4ERAB9A | |
| SCHEMBL6824033 | 0.71 | MAPT (0.49) | SMN1; SMN2ALDH1A1MAPTKDM4ERAB9A | |
| SCHEMBL31483496 | 0.71 | MAPT (0.49) | SMN1; SMN2ALDH1A1MAPTKDM4ERAB9A | |
| SCHEMBL16986060 | 0.71 | HPGD (0.47) | SMN1; SMN2ALDH1A1MAPTKDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963332-A1 | 1 H-INDAZOLES, BENZOTHIAZOLES, 1,2-BENZOISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND CHROMONES AND PREPARATION AND USES THEREOF | Memory Pharmaceuticals Corporation (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007056582-A1 | 1 H-INDAZOLES, BENZOTHIAZOLES, 1,2-BENZOISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND CHROMONES AND PREPARATION AND USES THEREOF | MEMORY PHARMACEUTICALS CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |