Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 16/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4701724 | 0.89 | BDKRB1 (0.42) | BDKRB1MEN1KMT2APAK1MAPT | |
| SCHEMBL4790289 | 0.89 | SIGMAR1 (0.48) | BDKRB1MEN1KMT2A | |
| SCHEMBL14084897 | 0.88 | BDKRB1 (0.60) | BDKRB1MEN1KMT2APAK1JAK2 | |
| SCHEMBL4705398 | 0.88 | BDKRB1 (0.59) | BDKRB1 | |
| SCHEMBL4705774 | 0.87 | BDKRB1 (0.50) | BDKRB1MEN1KMT2APAK1 | |
| SCHEMBL4789977 | 0.86 | BDKRB1 (0.46) | BDKRB1MEN1KMT2A | |
| SCHEMBL4703544 | 0.86 | BDKRB1 (0.68) | BDKRB1 | |
| SCHEMBL4788391 | 0.86 | BDKRB1 (0.42) | BDKRB1MEN1KMT2A | |
| SCHEMBL4790284 | 0.85 | ITGB1 (0.49) | BDKRB1RAB9ATDP1 | |
| SCHEMBL4706230 | 0.85 | CDK2 (0.48) | BDKRB1MEN1KMT2AMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633348-B1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARM INC (US) | 2008-10-08 | — | — | EP | claimed |