Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 9/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.38 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4790289 | 0.93 | SIGMAR1 (0.48) | BDKRB1SIGMAR1DRD4MEN1KMT2A | |
| SCHEMBL4701564 | 0.89 | GSK3B (0.47) | BDKRB1GSK3B | |
| SCHEMBL6045909 | 0.89 | BDKRB1 (0.50) | BDKRB1DRD4MEN1KMT2A | |
| SCHEMBL4789665 | 0.88 | BDKRB1 (0.53) | BDKRB1 | |
| SCHEMBL4788391 | 0.88 | BDKRB1 (0.42) | BDKRB1SIGMAR1MEN1KMT2AITGB1 | |
| SCHEMBL4700955 | 0.87 | SIGMAR1 (0.48) | SIGMAR1DRD4MEN1KMT2A | |
| SCHEMBL4700783 | 0.86 | BDKRB1 (0.53) | BDKRB1MEN1KMT2A | |
| SCHEMBL4701724 | 0.86 | BDKRB1 (0.42) | BDKRB1MEN1KMT2A | |
| SCHEMBL4704842 | 0.86 | DRD4 (0.46) | SIGMAR1DRD4 | |
| SCHEMBL4705037 | 0.86 | DRD4 (0.46) | SIGMAR1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633348-B1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARM INC (US) | 2008-10-08 | — | — | EP | claimed |