Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 7/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4705774 | 0.88 | BDKRB1 (0.50) | BDKRB1MEN1KMT2ACCNA2CDK2 | |
| SCHEMBL14084898 | 0.88 | BDKRB1 (0.47) | BDKRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL4706230 | 0.86 | CDK2 (0.48) | BDKRB1MEN1KMT2ACCNA2CDK2 | |
| SCHEMBL4790284 | 0.86 | ITGB1 (0.49) | BDKRB1CCNA2CDK2CCNA1 | |
| SCHEMBL4702034 | 0.86 | BDKRB1 (0.42) | BDKRB1KMT2ACCNA2CDK2CCNA1 | |
| SCHEMBL4700867 | 0.85 | BDKRB1 (0.46) | BDKRB1CCNA2CDK2CCNA1 | |
| SCHEMBL4790676 | 0.85 | CDK2 (0.42) | BDKRB1MEN1KMT2ACCNA2CDK2 | |
| SCHEMBL4704306 | 0.84 | BDKRB1 (0.45) | BDKRB1CCNA2CDK2CCNA1 | |
| SCHEMBL4790213 | 0.84 | BDKRB1 (0.41) | BDKRB1KMT2ACCNA2CDK2CCNA1 | |
| SCHEMBL4700955 | 0.82 | SIGMAR1 (0.48) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633348-B1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARM INC (US) | 2008-10-08 | — | — | EP | claimed |