Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | BDKRB1 | P46663 | 9/20 | 0.42 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.41 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4790284 | 0.91 | ITGB1 (0.49) | CDK2CCNA1CCNA2BDKRB1ITGB1 | |
| SCHEMBL4706230 | 0.91 | CDK2 (0.48) | CDK2CCNA1CCNA2BDKRB1ITGB1 | |
| SCHEMBL4705774 | 0.88 | BDKRB1 (0.50) | CDK2CCNA1CCNA2BDKRB1ITGB1 | |
| SCHEMBL4790213 | 0.87 | BDKRB1 (0.41) | CDK2CCNA1CCNA2BDKRB1ITGB1 | |
| SCHEMBL14084821 | 0.86 | CDK2 (0.45) | CDK2CCNA1CCNA2BDKRB1RAB9A | |
| SCHEMBL4705194 | 0.86 | BDKRB1 (0.45) | CDK2CCNA1CCNA2BDKRB1ITGB1 | |
| SCHEMBL4700796 | 0.85 | BDKRB1 (0.42) | CDK2CCNA1CCNA2BDKRB1KMT2A | |
| SCHEMBL4700955 | 0.85 | SIGMAR1 (0.48) | KMT2AMEN1 | |
| SCHEMBL4789701 | 0.84 | BDKRB1 (0.46) | CDK2CCNA1CCNA2BDKRB1ITGB1 | |
| SCHEMBL4703703 | 0.84 | MEN1 (0.46) | BDKRB1KMT2ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633348-B1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARM INC (US) | 2008-10-08 | — | — | EP | claimed |