Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 5/20 | 0.68 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | MAOB | P27338 | 8/20 | 0.63 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.61 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.56 |
| ▸ | BCHE | P06276 | 1/20 | 0.55 |
| ▸ | TLR4 | O00206 | 1/20 | 0.53 |
| ▸ | TLR2 | O60603 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.53 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.53 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.53 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.53 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.53 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4697138 | 0.86 | MAOB (0.67) | APPNPC1RAB9AMAOBGABRA1 | |
| SCHEMBL7917111 | 0.86 | MAOB (0.62) | APPNPC1RAB9ATDP1MAOB | |
| SCHEMBL27735405 | 0.85 | APP (0.77) | APPRAB9ATDP1MAOBBCHE | |
| SCHEMBL11300058 | 0.84 | MAOB (0.70) | APPNPC1RAB9AMAOB | |
| SCHEMBL10703087 | 0.84 | CHRNB2 (0.60) | APPNPC1RAB9AMAOBADRB3 | |
| SCHEMBL12183014 | 0.83 | MAOB (0.73) | APPNPC1RAB9ATDP1MAOB | |
| SCHEMBL13192722 | 0.83 | MAOB (0.72) | APPRAB9AMAOBSMN1; SMN2GABRA1 | |
| SCHEMBL22563 | 0.82 | ENPP2 (0.67) | APPNPC1RAB9ATDP1MAOB | |
| SCHEMBL13439834 | 0.82 | NPC1 (0.58) | APPNPC1RAB9ATDP1MAOB | |
| SCHEMBL29548398 | 0.82 | APP (0.71) | APPRAB9AMAOBSMPD1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9624239-B2 | Protein kinase inhibitors | PHARMASCIENCE INC. (CA) | 2017-04-18 | — | — | US | disclosed |
| US-9624239-B2 | Protein kinase inhibitors | PHARMASCIENCE INC. (CA) | 2017-04-18 | — | — | US | disclosed |
| EP-1926737-B1 | 4-AMINO-THIENO[3,2-C]PYRIDINE-7-CARBOXYLIC ACID DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-03-15 | — | — | EP | disclosed |
| EP-1926737-B1 | 4-AMINO-THIENO[3,2-C]PYRIDINE-7-CARBOXYLIC ACID DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-03-15 | — | — | EP | disclosed |
| CN-101263145-B | 4-amino-thieno [3,2-C ] pyridine-7-carboxylic acid derivatives | HOFFMANN LA ROCHE | 2015-02-25 | — | — | CN | disclosed |
| CN-104277051-A | 4-amino-thieno[3,2-c] pyridine-7-carboxylic acid derivatives | HOFFMANN LA ROCHE | 2015-01-14 | — | — | CN | disclosed |
| US-20140045833-A1 | Protein Kinase Inhibitors | PHARMASCIENCE INC. (CA) | 2014-02-13 | — | — | US | disclosed |
| US-20140045833-A1 | Protein Kinase Inhibitors | PHARMASCIENCE INC. (CA) | 2014-02-13 | — | — | US | disclosed |
| WO-2012135944-A9 | PROTEIN KINASE INHIBITORS | PHARMASCIENCE INC. (CA) | 2014-01-09 | — | — | WO | disclosed |
| WO-2012135944-A1 | PROTEIN KINASE INHIBITORS | PHARMASCIENCE INC. (CA) | 2012-10-11 | — | — | WO | disclosed |
| EP-1926737-A1 | 4-AMINO-THIENO[3,2-C]PYRIDINE-7-CARBOXYLIC ACID DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-06-04 | — | — | EP | disclosed |
| WO-2007031428-A1 | 4-AMINO-THIENO[3,2-C]PYRIDINE-7-CARBOXYLIC ACID DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-22 | — | — | WO | disclosed |
| WO-2007031428-A1 | 4-AMINO-THIENO[3,2-C]PYRIDINE-7-CARBOXYLIC ACID DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-22 | — | — | WO | disclosed |
| US-20070060607-A1 | 4-amino-thieno[3,2-c] pyridine-7-carboxylic acid derivatives | BARTKOVITZ DAVID J | 2007-03-15 | — | — | US | disclosed |
| US-20070060607-A1 | 4-amino-thieno[3,2-c] pyridine-7-carboxylic acid derivatives | BARTKOVITZ DAVID J | 2007-03-15 | — | — | US | disclosed |
| US-20070060607-A1 | 4-amino-thieno[3,2-c] pyridine-7-carboxylic acid derivatives | BARTKOVITZ DAVID J | 2007-03-15 | — | — | US | disclosed |
| EP-0044536-A1 | Plant growth regulators and their use | J.T. Baker Chemical Co. (US) | 1982-01-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140045833-A1 | Protein Kinase Inhibitors | LCK, BTK, TEC | APP 3370/4885NPC1 4309/4885RAB9A 3618/4885 |
| US-20070060607-A1 | 4-amino-thieno[3,2-c] pyridine-7-carboxylic acid derivatives | BRAF, RAF1, MAP3K7 | APP 4741/4885NPC1 3084/4885RAB9A 1577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.