Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 9/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.45 |
| ▸ | SSTR5 | P35346 | 3/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | TACR1 | P25103 | 3/20 | 0.38 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.36 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.35 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4701211 | 0.90 | SLC6A4 (0.44) | SLC6A2SLC6A4SLC6A3SSTR5KCNH2 | |
| SCHEMBL3973033 | 0.89 | SSTR5 (0.42) | SLC6A2SLC6A4SLC6A3SSTR5KCNH2 | |
| SCHEMBL4703414 | 0.86 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3SSTR5KCNH2 | |
| SCHEMBL4703982 | 0.86 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3SSTR5KCNH2 | |
| SCHEMBL4705277 | 0.84 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3SSTR5KCNH2 | |
| SCHEMBL3971901 | 0.82 | SSTR5 (0.43) | SLC6A2SLC6A4SLC6A3SSTR5KCNH2 | |
| SCHEMBL4702309 | 0.80 | REN (0.44) | SLC6A2SLC6A4SLC6A3RXRA | |
| SCHEMBL1121565 | 0.80 | SSTR5 (0.45) | SLC6A2SLC6A4SLC6A3SSTR5KCNH2 | |
| SCHEMBL4701120 | 0.80 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3SSTR5KCNH2 | |
| SCHEMBL3973372 | 0.79 | RXRA (0.41) | SLC6A2SLC6A4SLC6A3KCNH2RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001867-A2 | PYRIMIDINE, QUINAZOLINE, PTERIDINE AND TRIAZINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2008-12-17 | — | — | EP | disclosed |
| WO-2007110340-A2 | PYRIMIDINE, QUINAZOLINE, PTERIDINE AND TRIAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-04 | — | — | WO | disclosed |