Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 5/20 | 0.74 |
| ▸ | MAOB | P27338 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | LAP3 | P28838 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | BCHE | P06276 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2032141 | 0.87 | LTA4H (0.74) | LTA4HMAOBGAAMAPTMAOA | |
| SCHEMBL2027392 | 0.87 | LTA4H (0.74) | LTA4HMAOBGAAMAPTMAOA | |
| SCHEMBL5358938 | 0.87 | LTA4H (0.74) | LTA4HMAOBGAAMAPTMAOA | |
| SCHEMBL29399745 | 0.85 | LTA4H (1.00) | LTA4HMAOBGAAMAPTMAOA | |
| Hydrochloric Acid SCHEMBL4229807 | 0.85 | LTA4H (0.72) | LTA4HMAOBGAAMAPTMAOA | |
| SCHEMBL1893281 | 0.85 | LTA4H (1.00) | LTA4HMAOBGAAMAPTMAOA | |
| SCHEMBL1893279 | 0.85 | LTA4H (1.00) | LTA4HMAOBGAAMAPTMAOA | |
| SCHEMBL11216638 | 0.85 | LTA4H (0.72) | LTA4HMAOBGAAMAPTMAOA | |
| SCHEMBL13696737 | 0.85 | LTA4H (0.72) | LTA4HMAOBGAAMAPTMAOA | |
| SCHEMBL31307723 | 0.84 | LTA4H (0.55) | LTA4HMAOBMAPTRAB9APPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976828-A1 | DIAMINE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE | Schering Aktiengesellschaft (DE) | 2008-10-08 | — | — | EP | claimed |
| WO-2007079078-A1 | DIAMINE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2007-07-12 | — | — | WO | claimed |