Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 17/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4697895 | 0.92 | CRHR1 (0.42) | CRHR1MAPTTSHR | |
| SCHEMBL4701741 | 0.87 | CRHR1 (0.60) | CRHR1 | |
| Hydrochloric Acid SCHEMBL4700017 | 0.86 | CRHR1 (0.59) | CRHR1 | |
| SCHEMBL4702269 | 0.84 | CRHR1 (0.64) | CRHR1 | |
| SCHEMBL4757559 | 0.83 | CRHR1 (0.49) | CRHR1 | |
| SCHEMBL4698851 | 0.80 | CRHR1 (0.58) | CRHR1 | |
| SCHEMBL4700550 | 0.79 | CRHR1 (0.48) | CRHR1 | |
| SCHEMBL4700161 | 0.79 | CRHR1 (0.51) | CRHR1 | |
| Hydrochloric Acid SCHEMBL4697945 | 0.79 | CRHR1 (0.57) | CRHR1 | |
| SCHEMBL4702328 | 0.79 | CRHR1 (0.64) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569911-B1 | INDAZOLE DERIVATIVES AS CRF ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-02 | — | — | EP | claimed |