Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 20/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4700017 | 0.99 | CRHR1 (0.59) | CRHR1 | |
| SCHEMBL4698851 | 0.92 | CRHR1 (0.58) | CRHR1 | |
| Hydrochloric Acid SCHEMBL4697945 | 0.92 | CRHR1 (0.57) | CRHR1 | |
| SCHEMBL4702269 | 0.90 | CRHR1 (0.64) | CRHR1 | |
| SCHEMBL4702328 | 0.89 | CRHR1 (0.64) | CRHR1 | |
| SCHEMBL4697786 | 0.87 | CRHR1 (0.62) | CRHR1 | |
| SCHEMBL4757559 | 0.87 | CRHR1 (0.49) | CRHR1 | |
| SCHEMBL4701262 | 0.87 | CRHR1 (0.49) | CRHR1 | |
| Hydrochloric Acid SCHEMBL4701196 | 0.86 | CRHR1 (0.61) | CRHR1 | |
| Hydrochloric Acid SCHEMBL5349321 | 0.85 | CRHR1 (0.47) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569911-B1 | INDAZOLE DERIVATIVES AS CRF ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-02 | — | — | EP | claimed |
| EP-1569911-B1 | INDAZOLE DERIVATIVES AS CRF ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-02 | — | — | EP | disclosed |
| US-7214699-B2 | Indazole derivatives as CRF antagonists | ROCHE PALO ALTO LLC (US) | 2007-05-08 | — | — | US | disclosed |