Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | APAF1 | O14727 | 1/20 | 0.50 |
| ▸ | TDP2 | O95551 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26920799 | 0.84 | KMT2A (0.50) | KMT2AMEN1APAF1TDP2ALDH1A1 | |
| SCHEMBL621309 | 0.78 | KMT2A (0.54) | KMT2AMEN1APAF1TDP2ALDH1A1 | |
| SCHEMBL29855973 | 0.78 | KMT2A (0.54) | KMT2AMEN1APAF1TDP2ALDH1A1 | |
| SCHEMBL29862875 | 0.77 | KMT2A (0.50) | KMT2AMEN1APAF1TDP2ALDH1A1 | |
| SCHEMBL19836985 | 0.77 | KMT2A (0.50) | KMT2AMEN1APAF1TDP2ALDH1A1 | |
| SCHEMBL6956143 | 0.76 | KDM4E (0.45) | KMT2AMEN1ALDH1A1MAPTKDM4E | |
| SCHEMBL4700871 | 0.76 | KDM4E (0.57) | ALDH1A1MAPTKDM4ETDP1CYP3A4 | |
| SCHEMBL68709 | 0.75 | S1PR4 (0.41) | MAPTKDM4EHTTSMN1; SMN2GRM4 | |
| SCHEMBL30020489 | 0.75 | S1PR4 (0.41) | MAPTKDM4EHTTSMN1; SMN2GRM4 | |
| SCHEMBL29116878 | 0.75 | PKM (0.45) | KMT2AMEN1ALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116969941-A | PLpro protein inhibitor and preparation method and application thereof | 清华大学 | 2023-10-31 | — | — | CN | disclosed |
| CN-113825756-A | Substituted polycyclic carboxylic acids, analogs thereof, and methods of use thereof | 爱彼特生物制药公司 | 2021-12-21 | — | — | CN | disclosed |
| EP-0952832-B1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | DARWIN DISCOVERY LTD (GB) | 2008-08-27 | — | — | EP | disclosed |
| US-5804588-A | TREATING DISEASES THAT ARE MODULATED BY INHIBITION OF PHOSPHODIESTERASE IV OR TUMOUR NECROSIS FACTOR | CHIROSCIENCE LIMITED (GB) | 1998-09-08 | — | — | US | disclosed |