Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | METAP2 | P50579 | 1/20 | 0.54 |
| ▸ | METAP1 | P53582 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4701189 | 0.82 | NPC1 (0.47) | SMN1; SMN2LMNANPC1RAB9AL3MBTL1 | |
| SCHEMBL2654124 | 0.80 | NPC1 (0.77) | SMN1; SMN2LMNANPC1GAA | |
| SCHEMBL17404960 | 0.78 | NPC1 (0.68) | SMN1; SMN2LMNANPC1GAAALDH1A1 | |
| SCHEMBL21222595 | 0.76 | NPC1 (0.58) | NPC1RAB9ATDP1L3MBTL1ALDH1A1 | |
| SCHEMBL21222596 | 0.76 | NPC1 (0.58) | NPC1RAB9ATDP1L3MBTL1ALDH1A1 | |
| SCHEMBL8013302 | 0.76 | NPC1 (0.67) | SMN1; SMN2LMNANPC1RAB9AGAA | |
| Hydrochloric Acid SCHEMBL21640445 | 0.75 | NPC1 (0.57) | SMN1; SMN2NPC1RAB9ATDP1L3MBTL1 | |
| SCHEMBL25217762 | 0.75 | NPC1 (0.64) | SMN1; SMN2LMNANPC1RAB9AGAA | |
| SCHEMBL15594568 | 0.74 | NPC1 (0.46) | SMN1; SMN2LMNANPC1RAB9AGAA | |
| SCHEMBL15199106 | 0.74 | NPC1 (0.72) | SMN1; SMN2LMNANPC1RAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973890-A2 | INDANE MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-KB ACTIVITY AND USE THEREOF | Brystol-Myers Squibb Company (US) | 2008-10-01 | — | — | EP | claimed |
| WO-2007073503-A2 | INDANE MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-KB ACTIVITY AND USE THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-06-28 | — | — | WO | claimed |