Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.47 |
| ▸ | RAB9A | P51151 | 9/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | SCD | O00767 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4701294 | 0.82 | SMN1; SMN2 (0.57) | NPC1RAB9ASMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL4293350 | 0.73 | RAB9A (0.77) | NPC1RAB9ASMN1; SMN2LMNARECQL | |
| SCHEMBL2654124 | 0.72 | NPC1 (0.77) | NPC1SMN1; SMN2LMNAALOX15MAPK1 | |
| SCHEMBL4555606 | 0.71 | CHEK2 (0.36) | NPC1RAB9ASMN1; SMN2LMNARECQL | |
| SCHEMBL17404960 | 0.70 | NPC1 (0.68) | NPC1SMN1; SMN2LMNAALOX15MAPK1 | |
| SCHEMBL18394945 | 0.69 | NPC1 (0.63) | NPC1SMN1; SMN2LMNAALOX15MAPK1 | |
| SCHEMBL8013302 | 0.68 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2LMNAALOX15 | |
| SCHEMBL21222596 | 0.68 | NPC1 (0.58) | NPC1RAB9AL3MBTL1ALOX15POLB | |
| SCHEMBL21222595 | 0.68 | NPC1 (0.58) | NPC1RAB9AL3MBTL1ALOX15POLB | |
| SCHEMBL4286248 | 0.68 | RAB9A (0.72) | NPC1RAB9ASMN1; SMN2LMNARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973890-A2 | INDANE MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-KB ACTIVITY AND USE THEREOF | Brystol-Myers Squibb Company (US) | 2008-10-01 | — | — | EP | disclosed |
| WO-2007073503-A2 | INDANE MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-KB ACTIVITY AND USE THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-06-28 | — | — | WO | disclosed |