Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 6/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.41 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.41 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.41 |
| ▸ | ACR | P10323 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4697523 | 0.87 | MAPK14 (0.46) | KDM5BMAPK14DDR1DDR2ACR | |
| SCHEMBL4698884 | 0.83 | ACR (0.47) | MAPK14ACRMAPK8ADORA3ADORA2A | |
| SCHEMBL4696716 | 0.83 | ACR (0.44) | MAPK14ACRMAPK8FAAHADORA3 | |
| SCHEMBL4751605 | 0.80 | MAPK8 (0.41) | KDM5BMAPK14DDR1DDR2ACR | |
| SCHEMBL4697067 | 0.79 | PSEN1 (0.47) | KDM5BMAPK14ACRMAPK8ADORA3 | |
| SCHEMBL4697001 | 0.78 | MAPK8 (0.43) | KDM5BMAPK14DDR1DDR2ACR | |
| SCHEMBL4697999 | 0.77 | PSEN1 (0.47) | KDM5BMAPK14DDR1DDR2MAPK8 | |
| SCHEMBL4698770 | 0.77 | KDM5B (0.40) | KDM5BMAPK14DDR1DDR2ACR | |
| SCHEMBL4755672 | 0.77 | PSEN1 (0.51) | KDM5BMAPK8 | |
| SCHEMBL4700674 | 0.76 | KDM5B (0.39) | KDM5BMAPK14DDR1DDR2ACR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1735285-B1 | PYRAZOLE-AMINE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER PROD INC (US) | 2008-07-23 | — | — | EP | claimed |