Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 8/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | CCKBR | P32239 | 4/20 | 0.40 |
| ▸ | CCKAR | P32238 | 3/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PYGL | P06737 | 1/20 | 0.33 |
| ▸ | PYGM | P11217 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14084992 | 0.87 | BDKRB1 (0.51) | BDKRB1CCKBRCCKARRIPK1MEN1 | |
| SCHEMBL4701105 | 0.85 | CCKBR (0.40) | BDKRB1SCN9ACCKBRCCKARRIPK1 | |
| SCHEMBL4701967 | 0.79 | BDKRB1 (0.57) | BDKRB1MEN1KMT2AALDH1A1 | |
| SCHEMBL14084920 | 0.77 | RIPK1 (0.43) | BDKRB1CCKBRCCKARRIPK1 | |
| SCHEMBL6045843 | 0.77 | RIPK1 (0.43) | BDKRB1CCKBRCCKARRIPK1 | |
| SCHEMBL4701844 | 0.74 | BDKRB1 (0.42) | BDKRB1MEN1KMT2APOLB | |
| SCHEMBL4701720 | 0.74 | BDKRB1 (0.39) | BDKRB1SCN9ARIPK1 | |
| SCHEMBL4703604 | 0.72 | BDKRB1 (0.39) | BDKRB1CCKBRKMT2AALDH1A1CYP2D6 | |
| SCHEMBL4705804 | 0.72 | RIPK1 (0.37) | BDKRB1CCKBRCCKARRIPK1ALDH1A1 | |
| SCHEMBL4704015 | 0.72 | CCKBR (0.62) | BDKRB1CCKBRCCKAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633348-B1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARM INC (US) | 2008-10-08 | — | — | EP | claimed |