Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.46 |
| ▸ | HTR1A | P08908 | 8/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL4702260 | 0.94 | HSD11B1 (0.47) | HSD11B1OPRM1OPRL1HTR1A | |
| SCHEMBL4700535 | 0.91 | HSD11B1 (0.51) | HSD11B1OPRM1OPRL1HTR1AOPRK1 | |
| SCHEMBL4698781 | 0.91 | HSD11B1 (0.49) | HSD11B1OPRM1OPRL1HTR1A | |
| SCHEMBL4697970 | 0.89 | HSD11B1 (0.55) | HSD11B1OPRM1OPRL1HTR1AMTNR1A | |
| Hydrochloric Acid SCHEMBL4699238 | 0.88 | HSD11B1 (0.54) | HSD11B1OPRM1OPRL1HTR1AMTNR1A | |
| SCHEMBL2784645 | 0.88 | HSD11B1 (0.57) | HSD11B1OPRM1OPRL1HTR1AMTNR1A | |
| SCHEMBL4700555 | 0.86 | HSD11B1 (0.50) | HSD11B1OPRM1OPRL1 | |
| Citric Acid SCHEMBL4697783 | 0.85 | HSD11B1 (0.45) | HSD11B1OPRM1OPRL1HTR1AOPRK1 | |
| Citric Acid SCHEMBL4699943 | 0.84 | HSD11B1 (0.43) | HSD11B1OPRM1OPRL1 | |
| SCHEMBL2782154 | 0.83 | HSD11B1 (0.58) | HSD11B1OPRM1OPRL1HTR1AOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1560823-B1 | 4-SUBSTITUTED 1-AMINOCYCLOHEXANE DERIVATIVES FOR UTILIZATION AS ORL1-RECEPTOR AND MU-OPIATE RECEPTOR LIGANDS | GRUENENTHAL GMBH (DE) | 2008-07-09 | — | — | EP | claimed |
| EP-1560823-A1 | 4-SUBSTITUTED 1-AMINOCYCLOHEXANE DERIVATIVES FOR UTILIZATION AS ORL1-RECEPTOR AND MU-OPIATE RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2005-08-10 | — | — | EP | claimed |
| WO-2004043949-A1 | 4-SUBSTITUTED 1-AMINOCYCLOHEXANE DERIVATIVES FOR UTILIZATION AS ORL1-RECEPTOR AND MU-OPIATE RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2004-05-27 | — | — | WO | claimed |
| EP-1560823-B1 | 4-SUBSTITUTED 1-AMINOCYCLOHEXANE DERIVATIVES FOR UTILIZATION AS ORL1-RECEPTOR AND MU-OPIATE RECEPTOR LIGANDS | GRUENENTHAL GMBH (DE) | 2008-07-09 | — | — | EP | disclosed |
| EP-1560823-A1 | 4-SUBSTITUTED 1-AMINOCYCLOHEXANE DERIVATIVES FOR UTILIZATION AS ORL1-RECEPTOR AND MU-OPIATE RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2005-08-10 | — | — | EP | disclosed |
| WO-2004043949-A1 | 4-SUBSTITUTED 1-AMINOCYCLOHEXANE DERIVATIVES FOR UTILIZATION AS ORL1-RECEPTOR AND MU-OPIATE RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2004-05-27 | — | — | WO | disclosed |