Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 4/20 | 0.38 |
| ▸ | HTR7 | P34969 | 4/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4698781 | 0.95 | HSD11B1 (0.49) | HSD11B1KDM4EATMOPRL1OPRM1 | |
| SCHEMBL4702244 | 0.95 | HSD11B1 (0.47) | HSD11B1KDM4EATMOPRL1OPRM1 | |
| Citric Acid SCHEMBL4698211 | 0.93 | HSD11B1 (0.44) | HSD11B1KDM4EATMOPRL1OPRM1 | |
| Citric Acid SCHEMBL4699943 | 0.88 | HSD11B1 (0.43) | HSD11B1KDM4EATMOPRL1OPRM1 | |
| Citric Acid SCHEMBL4703734 | 0.88 | CHRM4 (0.41) | HSD11B1KDM4EOPRL1OPRM1BRD4 | |
| SCHEMBL4702254 | 0.86 | HSD11B1 (0.53) | HSD11B1OPRL1OPRM1 | |
| SCHEMBL4700535 | 0.86 | HSD11B1 (0.51) | HSD11B1OPRL1OPRM1HTR7 | |
| SCHEMBL4698866 | 0.86 | OPRL1 (0.47) | HSD11B1OPRL1OPRM1CHRM4CCR2 | |
| SCHEMBL2780700 | 0.86 | HSD11B1 (0.59) | HSD11B1KDM4EATMOPRL1OPRM1 | |
| SCHEMBL4699899 | 0.85 | MTNR1A (0.44) | HSD11B1CCR2HTR2AHTR7DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1560823-B1 | 4-SUBSTITUTED 1-AMINOCYCLOHEXANE DERIVATIVES FOR UTILIZATION AS ORL1-RECEPTOR AND MU-OPIATE RECEPTOR LIGANDS | GRUENENTHAL GMBH (DE) | 2008-07-09 | — | — | EP | disclosed |
| EP-1560823-A1 | 4-SUBSTITUTED 1-AMINOCYCLOHEXANE DERIVATIVES FOR UTILIZATION AS ORL1-RECEPTOR AND MU-OPIATE RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2005-08-10 | — | — | EP | disclosed |
| WO-2004043949-A1 | 4-SUBSTITUTED 1-AMINOCYCLOHEXANE DERIVATIVES FOR UTILIZATION AS ORL1-RECEPTOR AND MU-OPIATE RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2004-05-27 | — | — | WO | disclosed |