Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4703840 | 0.95 | KDM4E (0.45) | KDM4EPOLBCHEK1MEN1KMT2A | |
| SCHEMBL4705770 | 0.90 | CHEK1 (0.45) | KDM4EPOLBCHEK1 | |
| SCHEMBL4223869 | 0.88 | CHEK1 (0.53) | KDM4EPOLBHPGDSCHEK1HTR4 | |
| SCHEMBL4702659 | 0.88 | CHEK1 (0.58) | KDM4EPOLBCHEK1MEN1KMT2A | |
| SCHEMBL4705874 | 0.83 | CHEK1 (0.59) | KDM4ECHEK1RAB9ASMN1; SMN2 | |
| SCHEMBL4210074 | 0.83 | CHEK1 (0.54) | KDM4EPOLBCHEK1 | |
| SCHEMBL4704094 | 0.83 | CHEK1 (0.51) | KDM4ECHEK1MEN1KMT2ARAB9A | |
| SCHEMBL4702677 | 0.82 | CHEK1 (0.55) | CHEK1 | |
| SCHEMBL4704551 | 0.80 | KDM4E (0.49) | KDM4EPOLBCHEK1MEN1KMT2A | |
| SCHEMBL4704507 | 0.80 | CHEK1 (0.60) | CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660474-B1 | SUBSTITUTED THIOPHENES AND USES THEREOF | ASTRAZENECA AB (SE) | 2008-10-29 | — | — | EP | claimed |