Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 10/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | KLK7 | P49862 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CDK2AP1 | O14519 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4210048 | 0.90 | CHEK1 (0.44) | KDM4EPOLBCHEK1CDK2AP1CNR1 | |
| SCHEMBL4213189 | 0.90 | DYRK1A (0.46) | KDM4EPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL4223869 | 0.88 | CHEK1 (0.53) | KDM4EPOLBCHEK1HPGDSCDK2AP1 | |
| SCHEMBL4702638 | 0.86 | KDM4E (0.42) | KDM4EPOLBCHEK1HPGDSCDK2AP1 | |
| SCHEMBL4210074 | 0.85 | CHEK1 (0.54) | KDM4EPOLBCHEK1CDK2AP1 | |
| SCHEMBL5784504 | 0.83 | CHEK1 (0.55) | CHEK1CDK2AP1 | |
| SCHEMBL4209769 | 0.83 | CHEK1 (0.55) | CHEK1CDK2AP1 | |
| SCHEMBL5001107 | 0.83 | KDM4E (0.40) | KDM4EPOLBCHEK1MEN1KMT2A | |
| SCHEMBL5001102 | 0.83 | USP30 (0.43) | KDM4EPOLBCHEK1MEN1KMT2A | |
| SCHEMBL4214293 | 0.82 | CHEK1 (0.48) | KDM4EPOLBCHEK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660474-B1 | SUBSTITUTED THIOPHENES AND USES THEREOF | ASTRAZENECA AB (SE) | 2008-10-29 | — | — | EP | claimed |