Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 7/20 | 0.43 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | CDK2AP1 | O14519 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1563863 | 0.92 | USP30 (0.53) | USP30PBKBTKCHEK1PARP1 | |
| SCHEMBL4213189 | 0.91 | DYRK1A (0.46) | USP30KDM4EPOLBDYRK1AMEN1 | |
| SCHEMBL4210048 | 0.91 | CHEK1 (0.44) | KDM4EPOLBCHEK1CNR1CNR2 | |
| SCHEMBL1562936 | 0.90 | USP30 (0.55) | USP30PBKBTKCHEK1HDAC4 | |
| SCHEMBL4213212 | 0.87 | CHEK1 (0.52) | USP30PBKBTKCHEK1HDAC4 | |
| SCHEMBL4994970 | 0.85 | CHEK1 (0.56) | USP30CHEK1CDK2AP1 | |
| SCHEMBL4702638 | 0.84 | KDM4E (0.42) | KDM4EPOLBCHEK1DYRK1ACNR1 | |
| SCHEMBL5820429 | 0.84 | USP30 (0.53) | USP30PBKBTKCHEK1HDAC4 | |
| SCHEMBL4211957 | 0.83 | CHEK1 (0.54) | USP30PBKBTKCHEK1PARP1 | |
| SCHEMBL4703508 | 0.83 | KDM4E (0.46) | KDM4EPOLBCHEK1CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423061-B2 | Substitute thiophenes and uses thereof | ASTRAZENECA AB (SE) | 2008-09-09 | — | — | US | disclosed |
| US-20060281666-A1 | Substitute thiophenes and uses therof | ASTRAZENECA AB (SE) | 2006-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060281666-A1 | Substitute thiophenes and uses therof | TYMP, TPMT, MGMT | USP30 3894/4885PBK 1268/4885KDM4E 3570/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.