Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 12/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | CDK2AP1 | O14519 | 3/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4213189 | 0.90 | DYRK1A (0.46) | KDM4EPOLBDYRK1A | |
| SCHEMBL4703508 | 0.86 | KDM4E (0.46) | KDM4EPOLBCHEK1CDK2AP1CNR1 | |
| SCHEMBL4704937 | 0.84 | CHEK1 (0.55) | CHEK1CDK2AP1 | |
| SCHEMBL5001102 | 0.84 | USP30 (0.43) | KDM4EPOLBCHEK1DYRK1ACDK2AP1 | |
| SCHEMBL4223869 | 0.83 | CHEK1 (0.53) | KDM4EPOLBCHEK1CDK2AP1HPGDS | |
| SCHEMBL4706425 | 0.81 | CHEK1 (0.51) | KDM4ECHEK1CDK2AP1 | |
| SCHEMBL4210074 | 0.81 | CHEK1 (0.54) | KDM4EPOLBCHEK1CDK2AP1 | |
| SCHEMBL4210048 | 0.80 | CHEK1 (0.44) | KDM4EPOLBCHEK1CDK2AP1CNR1 | |
| SCHEMBL4706306 | 0.80 | CHEK1 (0.54) | CHEK1CDK2AP1 | |
| SCHEMBL4707220 | 0.80 | CHEK1 (0.53) | CHEK1CDK2AP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660474-B1 | SUBSTITUTED THIOPHENES AND USES THEREOF | ASTRAZENECA AB (SE) | 2008-10-29 | — | — | EP | claimed |