Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4703572 | 0.90 | KDM4E (0.42) | GPR119MAPTALDH1A1HTTKDM4E | |
| SCHEMBL4706555 | 0.89 | GPR119 (0.44) | GPR119MAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL4706887 | 0.88 | MAPT (0.46) | GPR119MAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL389349 | 0.88 | GPR119 (0.52) | GPR119MAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL4704876 | 0.87 | GPR119 (0.43) | GPR119MAPTALDH1A1HTTCTSB | |
| SCHEMBL4703083 | 0.87 | GPR119 (0.39) | GPR119MAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL4704968 | 0.87 | GPR119 (0.54) | GPR119MAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL4705333 | 0.86 | MAPT (0.40) | GPR119MAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL4705110 | 0.86 | MAPT (0.40) | GPR119MAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL4706883 | 0.86 | GPR119 (0.36) | GPR119MAPTALDH1A1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606282-B1 | PHENYL- AND PYRIDYLPIPEREIDINYE-DERIVATIVES AS MODULATORS OF GLUCOSE METABOLISM | ARENA PHARM INC (US) | 2008-11-12 | — | — | EP | claimed |