Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 7/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | S100A4 | P26447 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4705303 | 0.90 | GPR119 (0.53) | GPR119ALDH1A1CTSBMAPTLMNA | |
| SCHEMBL389248 | 0.88 | GPR119 (0.56) | GPR119ALDH1A1CTSBMAPTHPGD | |
| SCHEMBL4703671 | 0.87 | GPR119 (0.40) | GPR119ALDH1A1CTSBMAPTLMNA | |
| SCHEMBL4706555 | 0.86 | GPR119 (0.44) | GPR119ALDH1A1CTSBMAPTL3MBTL1 | |
| SCHEMBL4706887 | 0.86 | MAPT (0.46) | GPR119ALDH1A1CTSBMAPTHTT | |
| SCHEMBL4703083 | 0.85 | GPR119 (0.39) | GPR119ALDH1A1CTSBMAPTLMNA | |
| SCHEMBL1070995 | 0.85 | GPR119 (0.43) | GPR119ALDH1A1MAPTLMNAHPGD | |
| SCHEMBL4704968 | 0.85 | GPR119 (0.54) | GPR119ALDH1A1CTSBMAPTL3MBTL1 | |
| SCHEMBL4705333 | 0.84 | MAPT (0.40) | GPR119ALDH1A1CTSBMAPTLMNA | |
| SCHEMBL4705110 | 0.84 | MAPT (0.40) | GPR119ALDH1A1CTSBMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606282-B1 | PHENYL- AND PYRIDYLPIPEREIDINYE-DERIVATIVES AS MODULATORS OF GLUCOSE METABOLISM | ARENA PHARM INC (US) | 2008-11-12 | — | — | EP | claimed |