Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 7/20 | 0.45 |
| ▸ | LMNA | P02545 | 5/20 | 0.45 |
| ▸ | PKM | P14618 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | HTT | P42858 | 4/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 2/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.40 |
| ▸ | S1PR2 | O95136 | 3/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2492499 | 0.86 | NPC1 (0.51) | NNMTKMT2AMEN1NPC1LMNA | |
| SCHEMBL30195950 | 0.86 | NPC1 (0.51) | NNMTKMT2AMEN1NPC1LMNA | |
| SCHEMBL2495046 | 0.82 | MEN1 (0.55) | NNMTKMT2AMEN1NPC1LMNA | |
| SCHEMBL2371616 | 0.80 | NNMT (0.57) | NNMTKMT2AMEN1NPC1LMNA | |
| SCHEMBL29590839 | 0.80 | NNMT (0.57) | NNMTKMT2AMEN1NPC1LMNA | |
| SCHEMBL27956494 | 0.79 | JAK2 (0.45) | NNMTKMT2AMEN1NPC1LMNA | |
| Hydrochloric Acid SCHEMBL29629381 | 0.78 | NNMT (0.56) | NNMTKMT2AMEN1NPC1LMNA | |
| Hydrazine SCHEMBL4704048 | 0.78 | GABRP (0.57) | NNMTKMT2AMEN1NPC1LMNA | |
| SCHEMBL2491663 | 0.78 | GABRP (0.56) | NNMTKMT2AMEN1NPC1LMNA | |
| SCHEMBL4475387 | 0.78 | NNMT (0.50) | NNMTKMT2AMEN1NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966214-A1 | TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007075567-A1 | TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-07-05 | — | — | WO | disclosed |