Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 2/20 | 0.57 |
| ▸ | PARP1 | P09874 | 1/20 | 0.55 |
| ▸ | NQO2 | P16083 | 4/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8811070 | 0.86 | HPGDS (0.56) | HPGDSPARP1NQO2PDE10AMCHR1 | |
| SCHEMBL27741805 | 0.86 | HPGDS (0.56) | HPGDSPARP1NQO2PDE10AMCHR1 | |
| SCHEMBL13255540 | 0.83 | HPGDS (0.54) | HPGDSNQO2PDE10A | |
| SCHEMBL9308505 | 0.82 | PARP1 (0.53) | HPGDSPARP1LMNANPC1RAB9A | |
| SCHEMBL12020200 | 0.81 | HPGDS (0.51) | HPGDSNQO2PDE10ALMNANPC1 | |
| SCHEMBL9308502 | 0.80 | PARP1 (0.51) | HPGDSPARP1LMNANPC1RAB9A | |
| Jineol Methyl Ether SCHEMBL8613544 | 0.78 | HPGDS (0.62) | HPGDSPARP1NQO2PDE10AMCHR1 | |
| SCHEMBL434888 | 0.78 | HPGDS (0.62) | HPGDSPARP1NQO2MCHR1LMNA | |
| SCHEMBL5094347 | 0.78 | PARP1 (0.59) | PARP1MEN1KMT2APDE3BPDE3A | |
| SCHEMBL6171961 | 0.78 | PARP1 (0.59) | PARP1LMNASMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2802594-B1 | METAL COMPLEXES WITH DIBENZO[F,H]QUINOXALINES | UDC IRELAND LTD (IE) | 2017-04-19 | — | — | EP | disclosed |
| EP-0952832-B1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | DARWIN DISCOVERY LTD (GB) | 2008-08-27 | — | — | EP | disclosed |
| CN-1148189-C | Quinoline carboxamides as TNF inhibitors and as PDC-IV inhibitors | ��������ķ������ | 2004-05-05 | — | — | CN | disclosed |
| EP-0952832-A1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | Darwin Discovery Limited (GB) | 1999-11-03 | — | — | EP | disclosed |
| CN-1219131-A | Quinoline carboxamides as TNF inhibitors and as PDC-IV inhibitors | DARWIN DISCOVERY CO LTD (GB) | 1999-06-09 | — | — | CN | disclosed |
| US-5804588-A | TREATING DISEASES THAT ARE MODULATED BY INHIBITION OF PHOSPHODIESTERASE IV OR TUMOUR NECROSIS FACTOR | CHIROSCIENCE LIMITED (GB) | 1998-09-08 | — | — | US | disclosed |
| WO-1997044036-A1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 1997-11-27 | — | — | WO | disclosed |
| EP-0247277-B1 | PROCESS FOR THE PREPARATION OF 5-ALKYLQUINOLINIC ACIDS AND MEANS FOR CARRYING OUT THIS PROCESS | RÜTGERSWERKE AKTIENGESELLSCHAFT (DE) | 1991-09-11 | — | — | EP | disclosed |
| EP-0247277-A2 | Process for the preparation of 5-alkylquinolinic acids and means for carrying out this process | RÜTGERSWERKE AKTIENGESELLSCHAFT (DE) | 1987-12-02 | — | — | EP | disclosed |