Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 3/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4704868 | 1.00 | MAPK10 (0.45) | MAPK10MAPK8MAPK9HDAC1HDAC2 | |
| SCHEMBL4705137 | 1.00 | MAPK10 (0.45) | MAPK10MAPK8MAPK9HDAC1HDAC2 | |
| SCHEMBL4703791 | 0.80 | NPC1 (0.61) | MAPK10MAPK8MAPK9HPGDNPC1 | |
| SCHEMBL5634785 | 0.77 | L3MBTL1 (0.61) | MAPK10MAPK8HPGDNPC1RAB9A | |
| SCHEMBL4702630 | 0.75 | MAPK8 (0.47) | MAPK10MAPK8MAPK9HDAC1HDAC2 | |
| SCHEMBL23315078 | 0.68 | ALDH1A1 (0.47) | ALDH1A1MAPT | |
| SCHEMBL7457637 | 0.67 | NPSR1 (0.50) | MAPK10MAPK8HPGDNPC1SMN1; SMN2 | |
| SCHEMBL1094974 | 0.66 | ALDH1A1 (0.33) | ALDH1A1MAPT | |
| SCHEMBL1094973 | 0.66 | ALDH1A1 (0.33) | ALDH1A1MAPT | |
| SCHEMBL1094975 | 0.66 | ALDH1A1 (0.33) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1559714-B1 | Process for the preparation of 2-alkyl-3-aminothiophene derivatives and 3-aminothiophene derivatives | MITSUI CHEMICALS INC (JP) | 2008-01-09 | — | — | EP | disclosed |
| EP-1036793-B1 | A process for preparing 2-alkyl-3-aminothiophene derivative and 3-aminothiophene derivative | MITSUI CHEMICALS INC (JP) | 2005-09-07 | — | — | EP | disclosed |
| EP-1559714-A1 | Process for the preparation of 2-alkyl-3-aminothiophene derivatives and 3-aminothiophene derivatives | MITSUI CHEMICALS, INC. (JP) | 2005-08-03 | — | — | EP | disclosed |
| US-6331639-B2 | BY REACTING A 3-((ALKYL, ALKOXY, PHENYL OR HETEROARYL)CARBONYLAMINO)THIOPHENE WITH A KETONE IN THE PRESENCE OF AN ACID AND REDUCING THE REACTION MIXTURE; AGRICULTURAL FUNGICIDES | MITSUI CHEMICALS, INC. (JP) | 2001-12-18 | — | — | US | disclosed |
| US-6331634-B1 | FUNGICIDES | MITSUI CHEMICALS, INC. (JP) | 2001-12-18 | — | — | US | disclosed |
| US-20010023295-A1 | Process for preparing 2-alkyl-3-aminothiophene derivative and 3-aminothiophene derivative | KATSUTA HIROYUKI (JP) | 2001-09-20 | — | — | US | disclosed |
| US-6239282-B1 | ALKYLATING THE CORRESPONDING 3-AMIDOTHIOPHENE COMPOUND | MITSUI CHEMICALS, INC. (JP) | 2001-05-29 | — | — | US | disclosed |
| EP-1036793-A2 | A process for preparing 2-alkyl-3-aminothiophene derivative and 3-aminothiophene derivative | Mitsui Chemicals, Inc. (JP) | 2000-09-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010023295-A1 | Process for preparing 2-alkyl-3-aminothiophene derivative and 3-aminothiophene derivative | SULT1E1, CYP4B1, CYP3A4 | MAPK10 3769/4885MAPK8 4509/4885MAPK9 2790/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.