Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 4/20 | 0.41 |
| ▸ | REN | P00797 | 11/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | MBTPS1 | Q14703 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4682630 | 0.83 | REN (0.46) | RENKCNH2CYP3A4TACR1 | |
| SCHEMBL1750990 | 0.82 | REN (0.39) | C5AR1RENKCNH2CYP3A4 | |
| SCHEMBL4704492 | 0.81 | SMYD2 (0.39) | C5AR1KCNH2MBTPS1CYP3A4OPRM1 | |
| SCHEMBL661970 | 0.78 | REN (0.56) | RENKCNH2CYP3A4 | |
| SCHEMBL18567998 | 0.76 | MBTPS1 (0.51) | C5AR1MBTPS1OPRM1TACR1 | |
| SCHEMBL4701505 | 0.76 | SIGMAR1 (0.40) | OPRM1 | |
| SCHEMBL662616 | 0.73 | PSMB5 (0.39) | RENKCNH2CYP3A4TACR1 | |
| SCHEMBL1750638 | 0.72 | FFAR1 (0.51) | — | |
| SCHEMBL4682925 | 0.72 | REN (0.56) | RENKCNH2CYP3A4 | |
| SCHEMBL1751560 | 0.72 | REN (0.40) | RENKCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893578-A2 | NOVEL PIPERIDINE CARBOXYLIC ACID AMIDE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006129237-A2 | NOVEL PIPERIDINE CARBOXYLIC ACID AMIDE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2006-12-07 | — | — | WO | disclosed |