Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CDC7 | O00311 | 4/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.39 |
| ▸ | PIM1 | P11309 | 3/20 | 0.39 |
| ▸ | PRKACA | P17612 | 3/20 | 0.39 |
| ▸ | CDK2 | P24941 | 3/20 | 0.39 |
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4707398 | 0.87 | POLB (0.58) | POLBL3MBTL1HTTALDH1A1CDC7 | |
| SCHEMBL4707786 | 0.83 | AVPR1A (0.43) | POLBALDH1A1GAACDC7MAP4K4 | |
| SCHEMBL4705965 | 0.81 | POLB (0.48) | POLBL3MBTL1HTTALDH1A1CDC7 | |
| SCHEMBL4707028 | 0.78 | CDC7 (0.39) | POLBALDH1A1GAACDC7MAP4K4 | |
| SCHEMBL4705897 | 0.77 | PTAFR (0.40) | POLBALDH1A1GAACDC7MAP4K4 | |
| SCHEMBL4708709 | 0.75 | CDC7 (0.39) | POLBL3MBTL1HTTALDH1A1GAA | |
| SCHEMBL4706420 | 0.75 | IDO1 (0.44) | POLBHTTCDC7MAP4K4PIM1 | |
| SCHEMBL4638520 | 0.75 | ALDH1A1 (0.44) | POLBL3MBTL1HTTALDH1A1GAA | |
| SCHEMBL4706961 | 0.75 | IDO1 (0.40) | POLBALDH1A1GAACDC7MAP4K4 | |
| SCHEMBL4707828 | 0.75 | CDC7 (0.42) | POLBALDH1A1GAACDC7MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501809-B1 | TRIAZOLE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-01-16 | — | — | EP | disclosed |